The school, located on the Ho-Tokokoe road is about 10 minutes drive from Ho, the Capital of the Volta Region. Like all new institutions, the going was difficult. It was not easy to attract commuted teaching staff and students but Tanyigbe Community was determined to have a Secondary School at all cost, in order to curtail schooling in distant places by their children/wards.

The paramount chief, the late Togbe Kwasi Adiko, his sub-chiefs, and opinion leaders managed to have parcels of land around the then middle school released to the community for establishment of the school. Since the people of Tanyigbe were very much enthusiastic and interested in the establishing of a second cycle institution, they worked very hard through communal labour to build two teachers’ bungalows for which funds were provided by the government. Consequently almost all the buildings found on the compound currently were put up through communal labour while government and an NGO in one particular instance provided funds for the materials.

Since its existence, the school has had nine (9) Heads namely; Mr. A.K. Domorgah, Mr. Nyalemegbe Daniel K. Martin-Edu, Mr. Victor Akude, Mr. Godson K. Padmore-Tettey, Mr. I.C.B. Saku, Ms. Agnes Afesi-Afornu, Ms. Peace Abassah-Addo, Ms. Diana-Ross Akoi. Currently Mr. Bagmae Sarpong Solomon is the Headmaster of Tanyigbe Senior High School.

Between the years 2000 and 2002, the school’s enrolment dropped drastically and Ministry of Education signaled a possible closure if the community did nothing to improve the situation. Major General Anyidoho, one of the committed citizens of Tanyigbe accepted the challenge and together with the education Committee appointed by him, Mr. Benjamin Kpodo, Mr. Emmanuel Kwame Tide, Mr. Emmanuel Wuttor approached the Regional Director of Education in the persons of Miss Tawiah and Mr. Samuel Gyan.

After their own repeated investigations and general examination of the situation, Mr. Victor Akude, who was in charge of guidance and counselling in all second cycle institutions in the Volta Region at the time, agreed to leave his office to come to the rescue of the school. His personal drive, standard of discipline and encouragement to the community helped in many ways in restoring confidence in the school.

The Education committee under its chairmanship, Benjamin Kpodo also instituted competitive examinations for primary six pupils to ensure high standards at the entry point to Junior High Schools in order to ultimately raise the standards at the Senior High level. Another major initiative came from the Wutor family of Tanyigbe which established a major scholarship scheme for brilliant but needy students. That scheme which is still in existence is not limited to only Tanyigbe citizens but to any student that deserves the award.