St. Francis Girls Senior High, Jirapa was established by the Roman Catholic Church under the authority of the late Rt. Rev. Gabriel Chapagne, of the Missionaries of Africa, the then Bishop of Tamale and the late Cardinal Peter Porekuu Dery as co-founders in collaboration with the Sisters of the Franciscan Missionaries of Mary(FMM), an international women religious congregation in 1959 as the first girls' secondary school in North Ghana.