New Juaben Senior High School started as a private school established by Mr. G. Kwaku Adjei, a native of Asokore, Koforidua in 1953. New Juaben College of Commerce NJUACOCO (as it was then called ) became a Government Assisted Secondary School in 1965 and it was.re-named New Juaben Secondary Commercial School.

Daasebre Nana Kwaku Boateng (the then Omanhene of New Juaben Traditional Area) who graciously donated the land the school is currently occupying. A personality who was very instrumental in the building of the structures in the school was colonel George Minyilah.