St. James Seminary Senior High School was established in 1978 by the late Bishop of Roman Catholic Diocese of Sunyani Most Rev. James Owusu. In spite of the initial resistance and discouragement from many quarters, St. James Seminary opened as a private school with the admission of 14 students in the first year under the supervision of Monsignor Robert Mensah Abrampah as its first rector.
Awards and Achievements
| Year | Title of Award | Position |
|---|---|---|
| 2000 | Millennium Essay ( Sustainable National Development - Master Osei Anim Leonard ) | 1st |
| 2003 | Northern Sector Debate ( Overall best student - Master Augustine Abugri ) | |
| 2004 | Regional Quiz on Horticulture organized by Parks and Gardens | 1st |
| 2004 | Quiz on HIV/AIDS organized by ActionAid Ghana | 1st |
| 2004 | WAEC's Distinction Award for Producing The Second Best Candidate in the July/August 2004 SSCE | |
| 2005 | National Quiz Competition on Human Rights organized by Commission on Human Rights and Administrative Justice (CHRAJ) | 1st |
| 2006 | Topped the 2006 WASSCE ranking table | |
| 2007 | National Jubilee Debate organized by the Ghana Education Service | 1st |
| 2009 | Topped the 2009 WASSCE ranking table | |
| 2011 | Best academic performing school in WASSCE since 2011 | |
| 2013 | National Debate Competition | 2nd |
| 2013 | Queen mother's 40th Anniversary Debate Competition | 2nd |
| 2016 | WAEC's Distinction Award for Producing The Overall Best Candidate, West Africa and The Third Best Candidate, Ghana | |
| 2017 | Best Performing SHS at WASSCE Science | |
| 2017 | Best academic performing school in WASSCE since 2011 ( GES ) |